The role of physiotherapists in acute post-stroke neurorehabilitation: qualitative perspectives from clinicians and stroke unit managers.
Pérez-De La Cruz S
PURPOSE: The aim of this study was to explore and compare the perspectives of both physiotherapists and medical managers regarding the professional role and clinical contributions of physiotherapy...
PD-1 blockade promotes mucosal CD4+ T cell IL-10 production through altering microbiota to reduce intestinal ischemia reperfusion injury.
Wen SH, Zhang YN, Shen JT, Guo Y, Chang ZN, Zhang HF, Liu ZM, Zhang XY
PD-1 blockade therapy is widely used in clinical practice. Intestinal ischemia reperfusion (IR) injury is a serious clinical complication that leads to remote organ damage through disruption of the gu...
Dissecting burden of alcoholic cardiomyopathy: age-period-cohort analysis from the global burden of disease study 2019.
Zhou H, Mao Y, Zheng Z, Tu Z, Li Y, Yang J, Chen W, Fan C
BACKGROUND: Alcoholic cardiomyopathy (ACM) is a major cause of cardiovascular morbidity and mortality, characterized by ventricular dilation and impaired contractility resulting from chronic heavy...
Effects of time-restricted eating on blood pressure in children: A cluster randomized controlled trial.
Wu X, Miao J, Peng Z, An X, Liu Q, Chen L, Liang X
BACKGROUND: This study aimed to evaluate the safety and efficacy of a time-restricted eating (TRE) intervention to reduce blood pressure (BP) in children and adolescents. METHODS: We conducte...
Cardiometabolic index (CMI) and sarcopenia as predictors of all-cause and cardiovascular mortality in chronic kidney disease: a NHANES-based cohort study.
Zhang Z, Xing Y, Zhang F, Zhang X, Zhong Y
The Cardiometabolic Index (CMI) reflects visceral adiposity and lipid dysregulation, while sarcopenia indicates skeletal muscle depletion, both representing metabolic and functional decline in chronic...
Spontaneous intracranial artery dissection: risk factors, clinical features and imaging features.
Wang Y, Jiang Q, Chen X, Liang Q, Cao S, Wang F
PURPOSE: There remains a lack of epidemiological data and evidence regarding risk factors for intracranial arterial dissection (IAD) worldwide, making it difficult to make a more timely and accura...
Salvianolic acid C alleviates acute kidney injury by restoring fructose-1,6-bisphosphatase 1-mediated gluconeogenesis.
Chen J, Li Y, Zhou P, Zou S, Zhao J, Wu M, Wang L
This research was targeted to investigate the pharmacological effects and mechanisms of Salvianolic acid C (SAC), a natural compound extracted from the Chinese traditional herbal Danshen (), in acute ...
Is black carbon associated with cardiovascular and cancer mortality? Evidence from the Malmö Diet and Cancer Cohort.
Lawlor C, Malmqvist E, Oudin Åström D, Andersson Nystedt T, Bamberger J, Pira K, So R, Zhang J, Lim YH, Andersson ZJ, Stockfelt L, Oudin A
BACKGROUND: Black carbon (BC) is an air pollutant of growing concern due to its adverse impacts on health and climate. Growing evidence suggests that BC could have a number of negative impacts on ...
Tranexamic acid in spontaneous intracerebral hemorrhage: an updated systematic review and meta-analysis of randomized controlled trials.
Que C, Feng L, Lai X, Gao Y, Zhang H, Tao C, Kong L, Liu Z, Gao Y
BACKGROUND: Tranexamic acid (TXA) is a well-established antifibrinolytic medication in the general population. However, its efficacy and safety for patients with spontaneous intracerebral hemorrha...
Negative impact of very mild volume overload on the heart function in patients on chronic hemodialysis.
Michalickova K, Malik J, Valerianova A, Hruskova Z, Bednarova V, Lopot F, Buryskova Salajova K, Hladinova Z, Vychodilova T, Pesickova SS, Rocinova K, Tothova M, Szonowska B, Kratochvilova M, Kaiserova L, Janakova S, Tesar V
OBJECTIVES: Heart failure is associated with higher mortality of hemodialysis patients. Fluid overload is a major risk factor for cardiovascular disease in these patients, but it is frequently cli...
Prevalence of preserved ratio impaired spirometry: A systematic review and meta-analysis.
Li Y, Zhang P, Wang Y, Xu B, Chen T, Xie Y
OBJECTIVE: To summarise the prevalence of preserved ratio impaired spirometry (PRISm), intending to inform prevention strategies and clinical management. METHODS: We systematically searched P...
Ezetimibe alone for over 75 years old as a primary prevention to decrease cardiovascular events.
Vuorio A, Kovanen PT, Strandberg T
The EWTOPIA 75 (Ezetimibe Lipid-Lowering Trial on Prevention of Atherosclerotic Cardiovascular Disease in 75 or Older) study supports the reduction in the risk of atherosclerotic cardiovascular diseas...
Severe diffused glans penis venous malformation: successful management with 'fractional' Long-pulsed Nd: YAG laser therapy.
Jiang X, Liu H, Yang X, Ma G, Lin X, Hu L, Chen H
PURPOSE: To assess the efficacy and safety of 'fractional' long-pulsed Nd:YAG (FLP-Nd:YAG) for the treatment of severe diffused glans penis venous malformations (GPVM). METHODS: Thirteen pati...
Pre-pregnancy BMI, gestational weight gain trajectories, and new-onset hypertensive disorders in ART singleton pregnancies: a retrospective cohort study.
Ye W, Li Y, Li B, Zhu H, Wu Y, Guo D, Yu M, Xu J, Ji L
OBJECTIVE: To investigate non-linear associations between pre-pregnancy BMI and new-onset hypertensive disorders of pregnancy (HDP), and the relationship between gestational weight gain (GWG) traj...
Secondary poor graft function after autologous stem cell transplantation in multiple myeloma: a case-based expert review and successful rescue with secondary autologous stem cell infusion.
You J, Zhang Y, Meng Y, Liu X, Song X, Zhang J, Zang M, Suo J, Lu J, Dai Y, Meng J
INTRODUCTION: Secondary poor graft function (PGF) after autologous hematopoietic stem cell transplantation (Auto-HSCT) for multiple myeloma (MM) is rare, often delayed in recognition, and lacks st...
Propofol upregulates MFG‑E8 in BV2 cells to inhibit pyroptosis mediated by the NF‑κB/NLRP3 pathway, thereby ameliorating ischemic‑reperfusion neuronal injury.
Guo S, Zhen Y, Zhou G, Zhao Z
Abnormal activation and pyroptosis of microglia caused by cerebral ischemia‑reperfusion injury (CIRI) are key mechanisms underlying neuronal damage. The NF‑κB/NLRP3 pathway is a core mediator of micro...
Endothelial UNC5B regulates blood‑retinal barrier homeostasis.
Yao Y, Wang S, Li J, Jin Q, Chen Z, Jiang Q, Li K
The blood‑retinal barrier (BRB), a critical component of the retinal neurovascular unit (NVU), is essential for maintaining retinal homeostasis. Dysfunction of the BRB contributes to vascular leakage,...
METTL3-mediated N6-methyladenosine modification of modulates cardiomyocyte ferroptosis during myocardial infarction.
Zhang S, Xiang B, Zhao Y, Chen L, Meng D, Zhou X
Myocardial infarction (MI) affects millions of individuals worldwide, with ferroptosis recognized as a pivotal regulated cell death pathway in this context. N6-methyladenosine (m6A), the most prevalen...